The Missiquoi (or the Missisquoi or the Sokoki) are a Native American tribe located in the Wabanaki region of what now is northern Vermont and southern Quebec. This Algonquian group is a sub-group of the Abenaki who lived along the eastern shore of Lake Champlain at the time of the European incursion. Their name Missiassik, which "Missisquois" is derived, means "place of flint" in the Abenaki language; or alternatively, from "Masipskoik a word that means "place where there are boulders", more specifically "boulders point."

Today, the Missisiquoi tribe is known as the St. Francis-Sokoki Band of the Abenaki Nation of Missisquoi. It was recognized by the state of Vermont in 2012 after a nearly 40 year fight to be recognized by the state as a tribe and denial at the federal level. The tribe is currently organized by the Missisquoi Abenaki Tribal Council which is headquartered in Swanton, Vermont.