FIRE or F.I.R.E. may stand for:

  • FIRE economy, a segment of the stock market: Finance, Insurance, Real Estate
  • FIRE movement, a lifestyle movement: Financial Independence, Retire Early
  • Febrile infection-related epilepsy syndrome (FIRES), a rare form of epilepsy
  • Fellowship of Independent Reformed Evangelicals, a network of Reformed Baptist churches
  • Flyby of Io with Repeat Encounters, a proposed spacecraft mission to Jupiter's moon Io
  • Foundation for Individual Rights in Education, a civil liberties organization in the US
  • Fully Integrated Robotised Engine, a series of engines produced by Fiat
  • Future Internet Research and Experimentation, a program funded by the European Union
  • F.I.R.E., a 1991 shoot-em-up game developed by the Slovakian company Ultrasoft
  • F.I.R.E. (Free Inspiring Rising Elements), a Hmong and Lao performance group with May Lee-Yang
  • "F-I-R-E", a 2013 single by the American Christian group Press Play
  • Future in Reverse (FIRE), a performance group founded by composer Huang Ruo
  • Future Investors in Real Estate (F.I.R.E.), a student organization at Suffolk College of Arts and Sciences in Boston, Massachusetts, US